PDE5 Inhibitors: The Cure for ED

When you begin looking into male enhancement, you have to wade through a lot of scientific jargon. One phrase you’ll come across numerous times is “PDE5 inhibitors.” PDE5 inhibitors are common ingredients in male enhancement supplements, especially those focused on combatting erectile dysfunction.

PDE5 inhibitors are the first drugs or supplements prescribed or recommended to men with ED. Scientists have gained the ability to create PDE5 inhibitors in drug form, but they have also found that they are naturally present in certain herbs including Horny Goat Weed, Maca Root, Tribulus Terrestris, and Tongkat Ali.

PDE5 inhibitors work to help men get and retain erections because they block the action of cGMP-specific PDE5. By doing this, they allow smooth muscles along the blood vessels of the corpus cavernosum of the penis to relax and dilate with the release of nitric oxide. When they relax, more blood flows to the corpus cavernosum, resulting in a strong erection. Usually, cGMP decreases the strength of an erection, but because PDE5 inhibits its release, the effect of nitric oxide is increased.

Supplements are a common alternative to prescription PDE5 inhibitors like Viagra and Cialis because they don’t require a time-consuming and embarrassing doctor’s appointment. They’re also less likely to come with adverse side effects like dangerously low blood pressure. Unfortunately, PDE5 inhibitors aren’t for all men. The following health problems prevent certain men from being able to safely take drugs or supplements containing PDE5 inhibitors:

  • History of stroke or heart attack
  • Low or high blood pressure
  • Other heart diseases or disorders
  • Severe liver or kidney damage or disease

Common side effects upon taking drugs or supplements containing PDE5 include headache, nasal congestion, indigestion, and muscle pain. All of these side effects are due to the vasodilation in smooth muscles throughout the body, not just in the penis.

A notable difference between PDE5 inhibitors in drugs and supplements is their method of action. PDE5 inhibiting drugs typically affect the body much quicker as they are absorbed more quickly. This can be a good or bad thing depending on what the user is looking for. On the other hand, PDE5 inhibiting supplements have a slower, more mild yet long-term effect. Extended exposure to PDE5 inhibitors present in herbal supplements actually encourages the body to adapt to eventually gain an erection without PDE5 inhibitors. Supplements also tend to have more than one simple effect: the erection. They’re also designed to increase libido, sexual satisfaction, and even more control over one’s erection and orgasm timing. Although Viagra and Cialis are easy to take, they are not a long-term solution for ED unless taking them before all sexual activity can be considered a long-term solution.

PDE5 inhibitors are the key to treating ED these days, and they are a common ingredient in most male enhancement supplements. ED affects at least half of men aged 40 to 70 at some time, though younger men can also struggle with it. Male enhancement is about more than penis size: it’s also about being able to have erections on demand for a satisfying sex life for you and your partner.